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REVIEW ARTICLE Diagnosis of monoclonal gammopathy of renal significance Sofia O Correia, Sofia Santos, La Salete Martins, Josefina Santos
Monoclonal gammopathies are a heterogeneous group of disorders characterized by clonal proliferation of immunoglobulin produced by B-lymphocytes or plasma cell clone.
Port J Nephrol Hypert 2018; 32(1): 52-56 Advance Access publication 28 March 2018 DOWNLOAD PDF
REVIEW ARTICLE Off-target effects and adverse outcomes of fibroblast growth factor 23 in chronic kidney disease Giovana S. Di Marco, Marcus Brand
Chronic kidney disease (CKD) patients have a high risk of death, especially cardiovascular death.
Port J Nephrol Hypert 2018; 32(1): 57-63 Advance Access publication 28 March 2018 DOWNLOAD PDF
TUBULAR QUIZ An adult patient with hypokalemia Sandra Brum, Ana Rita Santos, Catarina Silveira, Fernando Nolasco, José Rueff, Joaquim Calado
SP, a southeast Asian male born in East Timor, was 53 years old by the time he came to our attention.
Port J Nephrol Hypert 2018; 32(1): 89-91 Advance Access publication 5 April 2018 DOWNLOAD PDF
PERSPECTIVE Seven years after "Norma 17": what has changed? Ana Farinha, Ana Branco
Although huge medical advances have been made in dialysis treatments, older patients with higher comorbidities or poorer functional status may have limited survival advantage.
Port J Nephrol Hypert 2018; 32(1): 11-15 Advance Access publication 28 March 2018 DOWNLOAD PDF
EDITORIAL Fighting glomerular hegemony: giving the renal tubule the credits it deserves Joaquim Calado
This new editorial feature, the tubular quiz, aims at renewing the interest of Portuguese nephrologists in both clinical evaluation and research in renal physiology and disorders that affect the renal tubule.
Port J Nephrol Hypert 2018; 32(1): 9-10 Advance Access publication 5 April 2018 DOWNLOAD PDF
REVIEW ARTICLE Supportive care in advanced chronic kidney disease: Comprehensive conservative care C Belino, C Meng, R Neto, E Gonçalves, M Pestana
Incident and prevalent patients on dialysis are progressively older, with high comorbidity burden and functional dependency.
Port J Nephrol Hypert 2018; 32(2): 149-158 Advance Access publication 25 May 2018 DOWNLOAD PDF
REVIEW ARTICLE The challenge of pregnancy after kidney transplantation Patrícia Cotovio
Kidney transplantation restores the impairment in fertility of end-stage renal disease patients.
Port J Nephrol Hypert 2018; 32(2): 143-148 Advance Access publication 7 June 2018 DOWNLOAD PDF
PERSPECTIVE Peritoneal Dialysis in the elderly: challenge accepted Alice Lança, Maria João Carvalho, Anabela Rodrigues
At present, mostly in Western countries, age is no longer an absolute limitation for renal replacement therapy (RRT); however, some elderly patients are still not considered for peritoneal dialysis (PD), mainly due to late referral, social isolation, low functional capacity or lower life expectancy.
Port J Nephrol Hypert 2018; 32(2): 101-109 Advance Access publication 28 March 2018 DOWNLOAD PDF
CASE REPORT Tubulointerstitial nephritis and uveitis syndrome (TINU) - à propos of 2 cases Ricardo A. Macau, Sara Barreto, Joana Martins, Joana Silva, Filipe Fraga, Rita T Manso, Pedro Bravo, Aura Ramos
The authors present two cases of tubulointerstitial nephritis and uveitis syndrome (TINU).
Port J Nephrol Hypert 2018; 32(2): 184-190 Advance Access publication 18 June 2018 DOWNLOAD PDF
CASE REPORT Acute tubulointersticial nephritis with uveitis: A report of two cases Filipa Silva, Sofia O Correia, Ana Castro, Carla Moreira, Sofia Santos, Jorge Malheiro, Josefina Santos, La Salete Martins, António Cabrita
Tubulointersticial nephritis and uveitis syndrome is an idiopathic and rare cause of acute kidney injury that should not overlooked, because it usually requires specific therapeutic interventions.
Port J Nephrol Hypert 2018; 32(2): 191-195 Advance Access publication 22 June 2018 DOWNLOAD PDF
REVIEW ARTICLE Kidney diseases with ocular involvement: a systematic review Rachele Escoli, Ricardo Oliveira, Paulo Santos, Ana Vila Lobos
Chronic kidney disease is an emerging health problem worldwide. The eye shares striking structural, developmental, and genetic pathways with the kidney, suggesting that kidney and ocular disease may be closely linked.
Port J Nephrol Hypert 2018; 32(3): 268-278 Advance Access publication 31 August 2018 DOWNLOAD PDF
REVIEW ARTICLE The role of bone biopsy in the management of patients with CKD - MBD C. Belino, C. Meng, L. Pereira, C. Carvalho, R. Neto, Frazão JM
The gold standard for diagnosis and classification of bone disorders is the transiliac crest bone biopsy.
Port J Nephrol Hypert 2018; 32(2): 159-164 Advance Access publication 22 June 2018 DOWNLOAD PDF
REVIEW ARTICLE Supportive care in advanced chronic kidney disease: Withholding and withdrawing dialysis therapy C Belino, C Meng, R Neto, E Gonçalves, M Pestana
Over the latest few decades, dialysis has been offered to older and more complex patients.
Port J Nephrol Hypert 2018; 32(2): 165-175 Advance Access publication 22 June 2018 DOWNLOAD PDF
EDITORIAL Tubulointerstitial Nephritis and TINU syndrome: A rising cause of acute kidney injury Ana Carina Ferreira
Much is written and studied about the glomerulus.
Port J Nephrol Hypert 2018; 32(2): 99-100 Advance Access publication 28 June 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Infectious risk of elderly patients on peritoneal dialysis: Experience of a portuguese center Carolina L Belino, Patrícia S Barreto, Maria C Santos, Ana M Gomes, Isabel Fonseca, João C Fernandes
Background: The goal of this study was to compare the risk of peritoneal dialysis‑related infections in younger and older patients and to identify risk factors for infection in elderly patients.
Port J Nephrol Hypert 2018; 32(2): 121-126 Advance Access publication 25 June 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Nutritional assessment of patients with chronic kidney disease under treatment with peritoneal dialysis Lívia Almeida Alvarenga, Michelle Andrade Moreira, Beatriz Cristina Pereira, Ana Paula Carlos Cândido, Aline Silva de Aguiar
Introduction: Peritoneal dialysis is a renal replacement therapy that allows the patient to live with a certain degree of autonomy and flexibility.
Port J Nephrol Hypert 2018; 32(2): 127-135 Advance Access publication 25 June 2018 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ An unlikely case although it exists Filipa B Mendes, Bernardo Marques da Costa, Mário Góis, Helena Viana, Ana Paula Silva, Fernando Nolasco
We present a case of 41-year-old man, native of Angola, accountant, who frequently visits Portugal.
Port J Nephrol Hypert 2018; 32(2): 196-200 Advance Access publication 27 June 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Evaluation of the Portuguese kidney transplant allocation system: comparative results from a simulation Bruno A Lima, Helena Alves
The distribution of such a scarce resource as deceased donor kidneys should be made by observing a balance between fairness, efficiency and flexibility.
Port J Nephrol Hypert 2018; 32(2): 136-142 Advance Access publication 28 June 2018 DOWNLOAD PDF
IN-DEPTH CASE DISCUSSION Making the diagnosis of Alport syndrome and the differential diagnosis of a severe superimposed second glomerulopathy in a young boy João Paulo Oliveira
In a previous issue of this journal, Neves et al.1 reported the occurrence of a severe,  normocomplementemic, acute nephritic syndrome at age 4½ years, in a boy with past medical history of self-limited episodes of macroscopic hematuria associated with respiratory infections, who was eventually diagnosed with Alport syndrome (AS) more than 10 years afterwards.
Port J Nephrol Hypert 2018; 32(2): 110-120 Advance Access publication 28 June 2018 DOWNLOAD PDF
TUBULAR QUIZ An adult patient with hypernatremia: a case of water balance equipoise Nuno Fonseca, Ana Messias, Ana Raquel Garrote, David Navarro, Orlando Cardoso, Fernando Maltez, Joaquim Calado, Fernando Nolasco
A 67‑year‑old black man from Cape Verde was admitted to our emergency department with a two‑day history of altered mental status and fever.
Port J Nephrol Hypert 2018; 32(2): 201-203 Advance Access publication 28 June 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Interventional nephrology - five years dealing with central stenosis: immediate and long-term results Helena Pinto, Emanuel Ferreira, Nuno Afonso, Catarina Teixeira, Fátima Costa, Rui Alves
Introduction: Improved technique and materials have allowed us to prolong the life of hemodialysis vascular access using percutaneous transluminal balloon angioplasty (PTA).
Port J Nephrol Hypert 2018; 32(3): 245-249 Advance Access publication 28 August 2018 DOWNLOAD PDF
CASE REPORT Immunoglobulin G4-related disease mimicking multiple myeloma Marta Sofia Costa, Andreia Silva, Luísa Costa, Ana Rodrigues, Tiago Barra, Sérgio Lemos, Jesús Garrido
Immunoglobulin G4‑related disease (IgG4‑RD) is a rare, poorly understood immune mediated disorder.
Port J Nephrol Hypert 2018; 32(3): 283-288 Advance Access publication 10 September 2018 DOWNLOAD PDF
CASE REPORT Light chain deposition disease: atypical associations in a rare disease Ivo Cunha, Sandra Silva, Rui Henrique, Maximino Costa
Light chain deposition disease is a systemic disorder characterized by deposition of monoclonal light chains in various organs.
Port J Nephrol Hypert 2018; 32(3): 289-292 Advance Access publication 21 September 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Peritoneal dialysis catheter placement with percutaneous technique with fluoroscopic guidance - our center's experience Joana R. Silva, Ricardo A. Macau, Joana M. Martins, Jorge Silva, Fernando T. Costa, Aura Ramos
Introduction: Studies have shown no clear superiority between surgical and percutaneous methods for peritoneal dialysis (PD) catheter insertion, so the preferred method usually depends on each center’s experience.
Port J Nephrol Hypert 2018; 32(3): 250-257 Advance Access publication 28 August 2018 DOWNLOAD PDF
REVIEW ARTICLE Cellular origin and regulation of kidney fibrosis Judith Schimpf, Rafael Kramann
Myofibroblasts take a key position as fibrosis driving, matrix secreting cells in kidney fibrosis and are thought to be important therapeutic targets in chronic kidney disease (CKD).
Port J Nephrol Hypert 2018; 32(3): 279-282 Advance Access publication 31 August 2018 DOWNLOAD PDF
PERSPECTIVE Transitions of care management in CKD: critical thinking and improving strategies Isabel M Correia, Anabela S Rodrigues
Chronic kidney disease (CKD) has a high clinical and socioeconomic impact and is often associated with multimorbidity.
Port J Nephrol Hypert 2018; 32(3): 233-244 Advance Access publication 27 September 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Nephrolithiasis in a portuguese pediatric population Joana V. Andrade, Sofia Bota, Telma Francisco, Raquel Santos, Gisela Neto, Margarida Abranches
Introduction and Aims: Nephrolithiasis incidence in children has increased considerably. It is associated with substantial morbidity, recurrence and increased adulthood cardiovascular risk and chronic kidney disease.
Port J Nephrol Hypert 2018; 32(3): 258-267 Advance Access publication 27 September 2018 DOWNLOAD PDF
CASE REPORT Intestinal obstruction in a patient on chronic hemodialysis Miguel Bigotte Vieira, Marta Pereira, Cristina Pinto de Abreu
Encapsulating peritoneal sclerosis (EPS) is an uncommon but serious complication of peritoneal dialysis (PD).
Port J Nephrol Hypert 2018; 32(3): 293-298 Advance Access publication 29 September 2018 DOWNLOAD PDF
CONSENSUS DOCUMENT Portuguese consensus document statement in diagnostic and management of atypical hemolytic uremic syndrome Ana Azevedo, Bernardo Faria, Catarina Teixeira, Fernanda Carvalho, Gisela Neto, Josefina Santos, Maria do Céu Santos, Nuno Oliveira, Teresa Fidalgo, Joaquim Calado
Among thrombotic microangiopathies (TMA), the hemolytic uremic syndrome associated with dysregulation of the alternative complement pathway (aHUS) is one of the most challenging diseases a nephrologist can face.
Port J Nephrol Hypert 2018; 32(3): 211-232 Advance Access publication 2 October 2018 DOWNLOAD PDF
CASE REPORT Arterio-arterial graft - an option for hemodialysis patients with exhaustion of venous patrimony Ana Castro, Paulo Almeida, Filipa Silva, Duarte Rego, Joana Tavares, Josefina Santos, Fernanda Silva, José Alexandre Queirós, António Cabrita, Rui Almeida
Introduction: Vascular access (VA) for hemodialysis (HD) is the lifeline for End Stage Renal Disease (ESRD) patients.
Port J Nephrol Hypert 2018; 32(3): 299-304 Advance Access publication 2 October 2018 DOWNLOAD PDF
NEPHROPATHOLOGY QUIZ What seems most likely may not be the case Filipa Cardoso, Joana Marques, Marco Mendes, Mário Góis, Helena Sousa, Fernando Nolasco
A 78-year-old Caucasian woman with a past medical history of hypertension, type 2 diabetes mellitus and dyslipidemia presented to the emergency department with fever (38°C), arterial hypertension (223/98mmHg) and non-bloody diarrhea.
Port J Nephrol Hypert 2018; 32(3): 305-308 Advance Access publication 3 October 2018 DOWNLOAD PDF
TUBULAR QUIZ A diabetic patient with glucosuria Joaquim Calado, Inês Aires, Vasco Fernandes, Fernando Nolasco, José Rueff
FMSB, an individual with type 2 diabetes mellitus (T2D), was referred to our Consulta de Doenças Renais Hereditárias at Hospital de Curry Cabral by his nephrologist, due to a disproportionate amount of glucosuria in light of his metabolic control.
Port J Nephrol Hypert 2018; 32(3): 309-312 Advance Access publication 3 October 2018 DOWNLOAD PDF
CASE REPORT Urinary schistosomiasis: a forgotten and challenging diagnosis Ana C. Castro, André Garrido, Maria J. Brito, Sara Pinto, Vanda Bento
Urinary schistosomiasis is a parasitic disease with a high global burden, especially in poor communities.
Port J Nephrol Hypert 2018; 32(4): 325-329 Advance Access publication 31 October 2018 DOWNLOAD PDF
CASE REPORT Persistent knee pain in a patient with systemic lupus erythematosus Miguel Bigotte Vieira, Joana Monteiro Dias, José Carlos Romeu, Marta Pereira, Cristina Pinto de Abreu
The evaluation of chronic kidney disease-mineral and bone disorder (CKD-MBD) is based on clinical, laboratory, radiology and histological data.
Port J Nephrol Hypert 2018; 32(4): 319-323 Advance Access publication 31 October 2018 DOWNLOAD PDF
REVIEW ARTICLE Renal denervation for resistant hypertension: a glimpse of hope on the horizon? Davide Bolignano
Renal denervation by a minimally‑invasive catheter‑based procedure has been extensively studied over the last decade as a powerful tool for treating resistant hypertension, a high‑risk condition the clinical management of which remains a major challenge.
Port J Nephrol Hypert 2018; 32(4): 343-349 Advance Access publication 7 December 2018 DOWNLOAD PDF
CASE REPORT Membranous nephropathy successfully treated with a Ponticelli regimen in a patient with HIV: do not assume that a well-known secondary cause is the real cause! Meng C, Pereira L, Guedes L, Nunes A, Pereira P, Frazão JM, Pestana M
Idiopathic membranous nephropathy with high-risk criteria for renal disease progression is considered an indication for immunosuppressive treatment.
Port J Nephrol Hypert 2018; 32(4): 331-336 Advance Access publication 7 December 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Infective endocarditis in renal transplant recipients: one center's experience Pereira L, Meng C, Guedes L, Marques S, Nunes A, Sampaio S, Tavares I, Bustorff M, Pestana M
Background: Infective endocarditis (IE) is rarely described among renal transplant recipients.
Port J Nephrol Hypert 2018; 32(4): 337-341 Advance Access publication 7 December 2018 DOWNLOAD PDF
ORIGINAL ARTICLE Urine volume and residual renal function decline among patients on peritoneal dialysis ? searching for associations Ricardo A. Macau, Joana R. Silva, Andreia Leite, Rita Magriço, Pedro Bravo, Fernando Teixeira e Costa, Aura Ramos
Introduction: Preservation of urine volume and residual renal function in patients on peritoneal dialysis (PD) is a major concern.
Port J Nephrol Hypert 2018; 32(1): 35-41 Advance Access publication 13 March 2018 DOWNLOAD PDF
CASE REPORT Coexistence of pheochromocytoma and renal artery stenosis in a pediatric patient with hypertension Inês Serras, Rute Baeta Baptista, Telma Francisco, Anaxore Casimiro, David Lito, Rui Alves, Margarida Abranches
Pheochromocytoma and renal artery stenosis are surgically treatable causes of hypertension.
Port J Nephrol Hypert 2018; 32(1): 78-82 Advance Access publication 13 March 2018 DOWNLOAD PDF
CASE REPORT C3 glomerulopathy: a rare kidney histological presentation of multiple myeloma Joana Silva Costa, Catarina Romãozinho, Luís Rodrigues, Carol Marinho, Vitor Sousa, Jorge Pratas, Maria Augusta Cipriano, Rui Alves
C3 Glomerulopathy is a rare disease caused by abnormal control of the alternative complement pathway, resulting in a predominant glomerular C3 deposition.
Port J Nephrol Hypert 2018; 32(1): 69-74 Advance Access publication 10 February 2018 DOWNLOAD PDF
CASE REPORT Prostate involvement in granulomatosis with polyangiitis: response to rituximab treatment David Navarro, Charles Pusey
Granulomatosis with polyangiitis is an autoimmune vasculitic condition strongly associated with anti-neutrophil cytoplasm antibodies.
Port J Nephrol Hypert 2018; 32(1): 75-77 Advance Access publication 10 February 2018 DOWNLOAD PDF
REVIEW ARTICLE Clinical implications of anti-HLA antibodies testing in kidney transplantation Jorge Malheiro, Sandra Tafulo
Alloantibodies against donor human leukocyte antigens (HLA), termed as donor‑specific antibodies (DSA), are one of the most important factors for both early and late kidney allograft dysfunction.
Port J Nephrol Hypert 2018; 32(1): 42-51 Advance Access publication 1 February 2018 DOWNLOAD PDF
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